The world's most trusted polynucleotide brand by Promoitalia. Complete range available — Strong, Medium, Hair, Eyes, Age, and CE variants. Direct to your US practice.
⚠️ Limited Stock — Ships Within 24 Hours — Free Shipping on Orders $500+
Polynucleotides (PNs) represent the next frontier in regenerative aesthetics. Derived from purified salmon DNA, these biopolymers stimulate your patients' own fibroblasts to produce new collagen and elastin.
Unlike hyaluronic acid that provides temporary volume, polynucleotides trigger biological regeneration — improving skin quality, texture, and elasticity from the cellular level up. Results build over weeks and last for months.
Nucleofill by Promoitalia is the original and most trusted PN brand, with the widest range of concentrations and targeted formulations for face, eyes, hair, and body.
Every formulation for every treatment area. Authentic, CE-marked, and ready for US delivery.
See how Nucleofill compares to other polynucleotide brands available.
| Product | PN Concentration | Volume | Origin | CE Mark | Our Price |
|---|---|---|---|---|---|
| Nucleofill Strong | 2.5% | 1.5ml | Italy | ✓ | $85.99 |
| Nucleofill Medium | 2.0% | 1.5ml | Italy | ✓ | $94.99 |
| Plinest | Undisclosed | 2ml | Italy | ✓ | $100.99 |
| PhilArt Injectable | Undisclosed | 2ml | Austria | ✓ | $111.99 |
| Rejuran Healer | Undisclosed | 2x2ml | South Korea | ✓ | $299.99 |
| Lumi Eyes | PN blend | 1ml | Europe | ✓ | $69.99 |
| Plenhyage XL Strong | Undisclosed | 2ml | Italy | ✓ | $111.99 |
Polynucleotides (PNs) are purified DNA fragments derived from salmon or trout. They work at a cellular level by binding to purinergic receptors on fibroblasts, stimulating the production of new collagen and elastin. This results in genuine tissue regeneration, improved skin texture, better hydration, and increased elasticity that builds over weeks.
Nucleofill Strong (2.5%) is ideal for general face rejuvenation and deep treatment. Medium (2%) is suited for sensitive areas and lighter treatments. Eyes Soft+ (0.75%) is specifically formulated for the delicate periorbital area. Hair Soft+ (2%) targets scalp regeneration for hair loss. Age Medium+ (2.5%) is designed for mature skin with higher regeneration needs.
Yes. All our Nucleofill products are 100% authentic, sourced from authorized Promoitalia distributors. Every unit is CE-marked with full batch traceability, expiry dates, and manufacturer verification. We are a licensed UK wholesale supplier.
We ship via DDP (Delivered Duty Paid) express service. All customs, duties, and import taxes are prepaid by us. Your order ships within 24 hours and arrives in 3-5 business days. Free shipping on orders over $500.
Subscribe for restock notifications, new variant launches, and subscriber-only discounts.