Everything US practitioners need to know about polynucleotide treatments. Compare all 7 major brands, understand the science, and order authentic products with DDP shipping.
Polynucleotides (PNs) represent the most significant advancement in regenerative aesthetics since hyaluronic acid. These purified DNA fragments, derived from salmon or trout, work at the cellular level to trigger genuine biological regeneration.
Unlike HA fillers that add temporary volume, PNs stimulate fibroblast activity — the cells responsible for producing collagen and elastin. The result is improved skin quality, texture, elasticity, and hydration that develops over weeks and lasts for months.
Side-by-side comparison of every major PN brand available for US practitioners.
| Brand | Origin | Variants | PN Concentration | Volume | CE Mark | Best For | From Price |
|---|---|---|---|---|---|---|---|
| Nucleofill | Italy | 8 variants | 0.75%-2.5% | 1.5-2.5ml | ✓ | Face, Eyes, Hair, Body | $80.99 |
| Plinest | Italy | 5 variants | Undisclosed | 2ml / 4ml vials | ✓ | Face, Eyes, Hair | $91.99 |
| PhilArt (Croma) | Austria | 4 variants | Undisclosed | 2ml | ✓ | Face, Eyes, Hair | $107.99 |
| Lumi Eyes | Europe | 2 variants | PN blend | 1ml | ✓ | Under-Eye Specialist | $69.99 |
| Rejuran | South Korea | 2 variants | Undisclosed | 1-2ml | ✓ | Premium Rejuvenation | $222.99 |
| Vitaran | South Korea | 4 variants | Undisclosed | 1-2ml | ✓ | Face, Eyes, Value | $77.99 |
| Plenhyage XL | Italy | 3 variants | Undisclosed | 2ml | ✓ | Face Rejuvenation | $111.99 |
Every polynucleotide brand, available for US delivery with DDP shipping.
The original polynucleotide brand with the widest range. Highest PN concentrations available (up to 2.5%). The most trusted name in PN treatments.
The most viral under-eye PN treatment. Specifically formulated for the delicate periorbital area. Phenomenal social media presence and patient demand.
Premium Italian PN range with versatile formulations. Plinest Eye is a top choice for periorbital treatments. Plinest Hair for scalp regeneration.
Austrian pharmaceutical quality PN treatments by Croma-Pharma. Known for consistent, reliable results. Injectable, Eye, Hair, and Next formulations.
Premium Korean PN brand. Rejuran Healer is the gold standard in Korean clinics. Higher price point reflects its established Korean market position.
Excellent value Korean PN brand. Vitaran Eyes is a popular Lumi Eyes alternative. Multiple syringe size options. Strong quality-to-price ratio.
Italian PN range with Strong, Medium, and Thin formulations. 2ml syringes with good concentration. Increasingly popular choice among UK and European practitioners.
Polynucleotides (PNs) are purified DNA fragments typically derived from salmon or trout. They bind to purinergic receptors (A2A) on fibroblasts, stimulating the production of new collagen and elastin. This triggers genuine biological tissue regeneration — improving skin quality, texture, hydration, and elasticity from the cellular level up. Results develop over 4-8 weeks and can last 6-12 months.
For the widest range and highest concentrations: Nucleofill. For under-eye specialist treatments: Lumi Eyes. For premium Italian quality: Plinest or PhilArt. For best value: Vitaran. For premium Korean quality: Rejuran. Many practitioners stock 2-3 brands to cover different treatment needs and price points.
PNs are CE-marked European medical devices. They are not yet FDA-approved but are widely used by US practitioners who source from international suppliers. Lumis Aesthetic ships all major PN brands to the USA via DDP shipping with all customs prepaid. Delivery takes 3-5 business days.
HA fillers add temporary volume by attracting water. PNs work differently — they stimulate your body's own regenerative processes. PNs are ideal for areas where volume isn't needed (under-eyes, neck, decolletage, hands) and for patients wanting genuine skin quality improvement rather than volumizing. Many practitioners combine both modalities.
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